Both are evenly matched on the odds at 9/10 at most book makers.
Coming into the tournament Anderson is the 8th seed and Isner is the 10th.
Both are huge servers so expect more scores of 40-0 and 40-15 on serves.
There is only 1 meeting on grass HU to reference too and Isner won 2-0 back in 2008.
Despite 5 meetings since 2012 Isner has won 4 and Anderson only 1 back in 2012.
Anderson moves much better than Isner which can be key on Grass courts.
Both play well at Wimbledon but Anderson far the better in recent years.
Anderson beating Roger Federer in the last round makes him peak for confidence and current form.
Isner has been struggling on fitness and stability for many months, this is his first decent run since marginal recovery.
7/11 sets of tennis played against each other have gone to tiebreaks (mostly on hard courts). That means there is a 63.63% chance of a tie-break (without taking into account other external elements of previous matches).
Kevin Anderson should be a favourite. The only thing pointing to Isner is the win-rate against Anderson however their last meeting was back in 2015 so this is better taken lightly.
I will be backing Anderson to win
(also smaller in-play bets on 40-0 each game to the server)