I know Troy Baker and Nolan North have their fanbase, but as far as I'm concerned the best EVER male performance of any video game is Benjamin Byron Davis as Dutch van der Linde. The human emotional complexity he has in RDR2 is unparalled. I strongly prefer it to the traditional choice of Joel in TLOU. For female performance, I've yet to see anyone top Melina Juergens's VGA award winning performance in Hellblade. Her vivid insanity is so captivating in that game.
His performance as Dutch was so captivating. I could honestly listen to Dutch speak all day, the emotion he conveys is much better than in a lot of actual films I've seen